Package: LatencyA
Type: Package
Title: Latency Analysis in Epidemiological Studies Using Weighted
        Cumulative Exposures
Version: 1.0.2
Authors@R: c(person(given = "Fuyu",family = "Guo",email = "fuyuguo@hsph.harvard.edu", role = c("aut", "cre")),
    person(given = "Zihan", family = "Qian", email = "zqian2@mgh.harvard.edu", role =  "aut"),
    person(given = "Molin", family = "Wang", email = "stmow@channing.harvard.edu", role =  "aut"))
Maintainer: Fuyu Guo <fuyuguo@hsph.harvard.edu>
Description: Implements weighted cumulative exposure Cox proportional
        hazards models for latency analysis with repeatedly measured,
        time-varying exposures. Instead of entering every lagged
        exposure as a separate and highly correlated covariate, the
        lag-specific log hazard ratios are constrained to follow a
        smooth function of the time since exposure, parameterized by
        natural cubic splines or polynomials, so that the susceptible
        window of an exposure can be identified from the estimated
        lag-risk curve. Functions are provided to fit models with a
        prespecified number of knots or polynomial degree, to select
        the number of knots by a grid search or the spline terms by a
        stepwise search using the Akaike or Bayesian information
        criterion, and to extract lag-specific log hazard ratios with
        their variances. For the data-driven model selection
        procedures, inference is based on a cluster bootstrap that
        resamples subjects, which can be run sequentially or in
        parallel. The methods are described in Guo, Qian, Wang, Wang,
        Rosner and Wang (2026) "Taking Into Account the Susceptible
        Window for Exposures in Cox Proportional Hazards Model: A Way
        Using Splines to Model the Lag-Risk Relationship"
        <doi:10.1002/sim.70755>.
Imports: Hmisc, survival, stats, MASS, stringr, future, furrr
License: MIT + file LICENSE
Encoding: UTF-8
LazyData: true
Depends: R (>= 4.1.0)
Config/roxygen2/version: 8.0.0
NeedsCompilation: no
Packaged: 2026-10-22 10:14:33 UTC; root
Author: Fuyu Guo [aut, cre], Zihan Qian [aut], Molin Wang [aut]
Config/pak/sysreqs: cmake make libicu-dev libuv1-dev
Repository: https://fyguo.r-universe.dev
Date/Publication: 2026-10-21 14:10:02 UTC
RemoteUrl: https://github.com/cran/LatencyA
RemoteRef: HEAD
RemoteSha: 814f6605f43c2f66d9042ce2fd8201c0c24ff292